Search on: ARACHIDONATE 12-LIPOXYGENASE 
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Descriptor English:   Arachidonate 12-Lipoxygenase 
Descriptor Spanish:   12-Lipoxigenasa Araquidonato 
Descriptor Portuguese:   Araquidonato 12-Lipoxigenase 
Synonyms English:   12-Lipoxygenase  
Tree Number:   D08.811.682.690.416.444.050.060
D12.776.556.579.374.450.025.025
Definition English:   An enzyme that catalyzes the oxidation of arachidonic acid to yield 12-hydroperoxyarachidonate (12-HPETE) which is itself rapidly converted by a peroxidase to 12-hydroxy-5,8,10,14-eicosatetraenoate (12-HETE). The 12-hydroperoxides are preferentially formed in platelets. EC 1.13.11.31. 
History Note English:   91(87); was see under ARACHIDONATE LIPOXYGENASES 1987-90 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DU diagnostic use DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   19075 
Unique Identifier:   D001092 

Occurrence in VHL:
 

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